ANTIBIOTIK REZISTENTLIK RIVOJLANISH MEXANIZMLARI VA UNI CHEKLASH STRATEGIYALARI
Keywords:
Antibiotiklar, rezistentlik, antimikrob ta’sir, mikroorganizmlar, efflyuks nasoslari, β-laktamazalar, genetik mutatsiyalar, gorizontal gen transferi.Abstract
Ushbu maqolada Antibiotik rezistentlik ning molekulyar-biokimyoviy mexanizmlari va shakllanish omillari kompleks tahlil qilinadi. Antibiotiklarning bakterial hujayra darajasidagi farmakodinamik nishonlari hamda ularning ta’sir xususiyatlari yoritiladi. Rezistentlikning genetik asoslari, xususan mutatsiyalar va gorizontal gen transferi jarayonlari ilmiy jihatdan asoslanadi. Shuningdek, antibiotiklardan irratsional foydalanishning klinik va epidemiologik oqibatlari baholanadi hamda uni cheklashning zamonaviy strategiyalari taklif etiladi.
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