PATHOGENETIC TREATMENT OF CHRONIC CYSTITIS BASED ON UROTHELIAL BARRIER RESTORATION AND LOCAL IMMUNE MODULATION
Abstract
Chronic cystitis is a recurrent inflammatory bladder disorder that significantly impairs quality of life, particularly among women aged 25–55 in Uzbekistan. Standard symptomatic and antibacterial therapies provide temporary relief but fail to address underlying pathogenetic mechanisms such as urothelial barrier dysfunction, chronic immune activation, and microbial dysbiosis. Developing pathogenetically oriented treatment strategies is therefore essential for long-term disease control, recurrence prevention, and reduced antibiotic overuse.
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