THE IMPORTANCE OF NEUROPHYSIOLOGICAL AND CLINICAL-LABORATORY INDICATORS IN THE ASSESSMENT OF INSOMNIA DURING THE EARLY RECOVERY PERIOD OF ACUTE ISCHEMIC STROKE
Abstract
In the early recovery period after acute ischemic stroke, insomnia occurs at high frequency, significantly negatively affecting the cognitive functions, emotional state and general functional recovery process of patients. Sleep-wakefulness rhythm disturbances can lead to stunted neuroplastic processes, decreased memory and attention functions, and increased depressive and anxious states. In the pathogenesis of insomnia, neurophysiological changes in the central nervous system, especially dysbalance of bioelectric activity, as well as increased activity of the hypothalamic–pituitary–adrenal (HPA) stress system, are important. In addition, the activation of inflammatory mediators and hormonal regulation disorders cause sleep architecture to be derailed. Therefore, in-depth study of insomnia based on neurophysiological and clinical-laboratory indicators is relevant for the development of early diagnostics and effective rehabilitation strategies.
References
1. Ajermacheva M. N., Alifirova V. M., Plotnikov D. M., Aliev O. I., Solovsov M. A., Burkova K. I., Plotnikov M. B., Pokazateli endotelialnoy dysfunctsii i rheologicheskie svoystva krovi v Ostrom periode ishemicheskogo insulta // Annali klinicheskoy I experimentalnoy neurologii. - 2016. - T. 10, № 1. - 14-19 b.
2. Azin A.L., Yakimova M.E., Kublanov B.S. Ultrazvukovoy analiz I vozmojnost elektroimpulsnoy korrektsii izmeneniy v serdechno–sosudistoy sisteme u lis s oskorennim stareniem//Vestnik Uralskoy medisinskoy akademicheskoy nauki. – 2012. – № 3 (40). – 48-49 b.
3. Aleksandrov S. G. Functionalnaya asymmetry I mezhpolusharnie vzaimodeystviya golovnogo mozga: Uchebnoe posobie dlya studentov / / S. G. Alexandrov; GBOU VPO" IGMU " Minzdrava Rossii, departmental normalnoy physiologii - Irkutsk: IGMU.2014.- 62 b.
4. Alekyan B. G., Abugov S. A., Andreev D. A., Buryachkovskaya L. I., Vavilova T. V., Vershinina M. G., Vorobeva N. A., Ivanova G. E., Lomakin N. V., Meshkova K. S., Pokrovsky A. V., Stakhovskaya L. V., Sichev D. A., Rol testirovaniya functionalnoy aktivnosti trombositov v prophylactike serdechno-sosudistix oslozhneniy U bolnix, poluchayutshix antithrombositarnuyu terapiyu // Rationalnaya pharmacotherapy v cardiologii. - 2014. - T. 10, № 6. - 679-687 PP.
5. Asrorov A. A., Aminjonová Ch. A. Otsenka sostoyaniya kognitivnix narusheniy u pasientov perenesshix stroke V praktike semeynogo vracha //Central asiap Journal of medical and natural ssiepses. – 2021. – 397-401 b.
6. Anaskaya L.H. Osobennosti ishemicheskogo insulta U lyudey pojilogo vozrasta / / medisinskie Novosti. – 2011. – №1. 10-12 b.
7. Alikulova N.A., Features of clinical neurological and hemodynamic disorders in men and women in the aspect of brain functional asymmetry of post-stroke syndromes // 2022. Dissertation. 13-14 b.
8. Aronov D. M., Kaskad therapeuticheskix effektov statinov / / Cardiology. - 2004. - T. 44, № 10. - 85-94 b.
9. Ayrapetov K.B, Aculenoc E.A., Golovanova E.D frequency vstrechaemosti, stratification riska, techenie I medikamentoznoe lechenie arter alnoy hypertenzii U jentshin v postmenopauzalnom periode// Ssiepses of Eigorep № 60.(2020).- 9-10 b.
10. Baranova O. A., Chekanov A. V., Karneev A. N., Mironova O. P., Myachin I. V., Panasenko O. M., Soloveva E. Yu., Fedin A. I., Poisk novix markerov okislitelnogo stressa pri ishemii mozga dlya optimizasii therapeuticheskix podhodov / / Journal neurologii I psychiatrii im. S.S. Korsakova. - 2011. - T. 111, № 12. - 25-31 b.
11. Barkagan Z. S., Momot A. P., Diagnostic I controliruemaya therapy narushenium hemostase / / m: Newdiamed. - 2001. - 286 -287 b.
12. Belopasova A. V., Kadikov A. S., Pryanikov I. V., Pryanikova N. I., Analysis structure I dinamiki rechevix function V techenie pervogo goda posle ishemicheskogo insulta / / fizicheskaya i reabilitasionnaya medisina, medisinskaya rehabilitation. - 2019. - T. 2, № 2 (2). - 19-23 b.
13. Bogolepova A.N., Vedenie komorbidnogo pasienta s tserebrovaskulyarnoy pathologiey na fone arterialnoy hypertonii I saxarnogo diabeta // nervnie bolezni. - 2018. - № 4. - 15-20 b.
14. Voznyuk I.A. Tserebralnaya hemodynamics u lis s nachalnimi proyavleniyami nedostatochnosti krovosnabjeniya mozga: Autoreferat dis. ... kand. med. nauk / I.A. Voznyuk. - Spb., 1994. – 34 b.
