STUDY OF MORPHOLOGICAL CHANGES IN THE FRONTAL CORTEX OF THE CEREBRAL HEMISPHERES AFTER CORRECTION WITH MILK THISTLE EXTRACT IN EXPERIMENTAL CARBON MONOXIDE INTOXICATION IN WHITE OUTBRED RATS DURING POSTNATAL ONTOGENESIS
Abstract
Aim of the study. The aim of this study was to identify morphological and morphometric changes in the frontal cortex of the cerebral hemispheres in 18-month-old white outbred rats under conditions of chronic carbon monoxide intoxication, as well as to evaluate the neuroprotective effect of correction with Silybum marianum (milk thistle) extract.
References
1. Aliev H.M., Rakhimov F.N. Histological changes in the microcirculatory bed of the brain under carbon monoxide intoxication // Pathological Physiology and Experimental Therapy. – 2021. – Vol. 65, No. 4. – P. 34–39.
2. Bekmurodov B.T., Yuldashev N.K. Morphometric characteristics of neocortical neurons in aging rats // Journal of Anatomy and Histopathology. – 2022. – Vol. 11, No. 3. – P. 42–47.
3. Ganiev K.K., Ismoilov J.A. Cytological features of neuronal degeneration in hypoxic brain injury // Archives of Pathology. – 2019. – Vol. 81, No. 5. – P. 51–56.
4. Abenavoli L., Izzo A.A., Milic N. et al. Milk thistle (Silybum marianum): A concise overview on its chemistry and pharmacological uses // Phytotherapy Research. – 2018. – Vol. 32, No. 11. – P. 2202–2213.